Ten years after the Holy War in Hong Kong, Mochizuki Jirou, aka the Silver Blade, and the lone hero who fought and defeated the Kowloon Children despite the loss of his lover, returns to Japan with his young brother, Mochizuki Kotarou. The two quickly discover that the Kowloon Children who survived the Holy War are seeking to infiltrate the "Special Zone", a thriving city protected by an invisible barrier that will not allow Kowloon Children entrance, unless they're invited. Red Bloods refers to the humans; Black Bloods are the vampires, and the Mochizuki Brothers are Old Blood, the last descendants of an elite clan of vampires. When Kotarou is abducted by one of the Kowloon Children, Jirou has no choice but to fight once more.

In recent years, creatures known as Kaii have frequently attacked cities and wrought destruction. Exterminating these monsters quickly became a popular and well-respected profession, carried out by magical girls. More than five hundred magical girl companies, ranging from small ventures to large corporations, offer their aid to those who need it. Kana Sakuragi is a studious college graduate struggling to land a job despite attending numerous interviews. But when a Kaii attacks during her latest interview, she finds herself assisting the magical girl responding to the crisis. Although she lacks battle experience, Kana relies on her exceptional memory and knowledge to help subdue the monster. Hitomi Koshigaya, the headstrong magical girl who faced the Kaii, recognizes Kana's potential and invites her to join Magilumiere Magical Girls Inc.—the startup where Hitomi works. Wishing to make a difference, Kana accepts the offer to become a magical girl herself. While Kana may not be suited for the corporate world, it soon becomes clear that her true calling is to rise as one of the most talented magical girls in existence.

Demonic activity worldwide has significantly increased due to the involvement and corrupt practices of the Illuminati. To combat the unnatural influx of demons, the Vatican Headquarters decides to hold the annual Exorcist Certification Exam early and allow for as many exorcists as possible to take up the mantle. Straight from the Vatican, one of the most powerful exorcists, Lewin "Lightning" Light, arrives at True Cross Academy to help prepare the students for the exam. The ease and mastery with which Lewin performs exorcisms quickly impresses Ryuuji "Bon" Suguro, who has lost his ambition to continue his studies, and Lewin surprisingly accepts him as his apprentice. Amid the worsening situation, twin brothers Rin and Yukio Okumura are sent to locate the recently missing exorcist Shura Kirigakure, who seems to be chained to a decades-long contract with a powerful, immortal demon hiding in Aomori Prefecture's dangerous, snowy mountains.

During their martial arts training expedition in China, Ranma Saotome and his father Genma suffered an accident, which in turn, afflicted them with a curse—whenever they are doused with cold water, Ranma transforms into a girl, while his father turns into a panda! Only hot water can reverse these changes, but any further contact with cold water opens the can of worms once more. Unfortunately, the trouble does not end there, as Ranma finds out about his betrothal to one of the daughters of Soun Tendou, his father's closest friend. During the families' first meeting, it is decided that Ranma is to be married to Akane, the youngest daughter, a decision that is met with vehement protests from both sides. The two are simply not compatible, yet they are forced to live under one roof. Ranma's status quo further adds to the chaos, leading him to a series of comedic situations and misunderstandings that, in the grand scheme of things, may just be what he needs to work with Akane.