Doppo Orochi sits down to watch the final match of his karate school's youth tournament. Atsushi Suedou, one of his disciples, faces off against Baki Hanma, a fresh teenage boy breezing through the matches. Intrigued by the boy's strength, Doppo, alongside another of his disciples—Kiyosumi Katou— visits the notorious Tokugawa underground ring—a hidden freestyle fighting arena that prohibits only weaponry in its matches. Upon arriving, they learn that Baki is set to face none other than Koushou Shinogi: an infamous karate master and user of the lethal Cord-Cutting technique.

Catian Eris is now on a mission to learn about Earth games and how they are played, but she seems to think that bets have to be placed every time. And while some bets are material items, eventually the Catians learn about betting items of clothing...

After toiling away in his lab, the alchemist Jolly has finally succeeded in making a personality-swapping potion that is guaranteed to bring him entertainment. The boys of the Arcana Famiglia are tricked into taking the potion and find themselves in bodies that are not their own. With this successful experiment, Jolly has paved the way for a plethora of uncomfortable scenarios. However, despite the boys' desperate struggle to switch themselves back, there is something to be learned from spending the day in someone else's shoes.

These events occur in Westland, New York, during the 21st century. With a sharp knife, a murderer is indiscriminately killing people… A girl witnesses one of these murders, and the knife is turned on the helpless girl shaking with fear. Meg returns to this town with Joe to celebrate the “birthday” of Shirley, who used to live with Meg. Orphans, they had decided that the day they first met would be her birthday. In the past, Meg had taken care of three little children, including Shirley, just before meeting Joe. The children were then adopted by a police officer, Sam. He possessed a strong sense of justice and they are supposedly living happily together now. Meg and Joe happen to help a person and receive a reward. They buy a present for Shirley with the reward money and go to meet Sam. However, they notice him acting strangely. Upon questioning him, he explains that Shirley was assaulted by a murderer and seriously injured. Joe says to the grieving and angry Meg, “Let's exact revenge on the murderer for Shirley.” However, the murderer gradually approaches them from behind. The cruel black eyes fall on Meg and Joe… To make matters worse, a dark plot casts its shadow over Meg, Joe, Sam, and the whole town.