The anime centers on two protagonists. Koma Jinguji (Jay) is the smart and handsome student council president. His elegant smile captures the hearts of women. Tsubasa Hayakawa is a multi-talented and gentle shop assistant at a café. His cafe latte with owl latte art is very popular with female customers. The two men travel through time to fight their archenemy. The charming "Butlers," as they are called, fight supernatural battles and also experience a slapstick comedic life at their academy. (Source: ANN)

Isanami, a young priestess of Izumo, is forced to watch as a group of evil ninja burn her temple to the ground and slaughter the people within, leaving her no choice but to flee into the forest to escape the same fate. By chance, she stumbles upon Saizou Kirigakure, a masterless ninja from the Iga school. The two travel to Ueda Castle to ask Yukimura Sanada for help. Isanami's possession of a strange and devastating power is revealed, and Sanada readily agrees to help her, gathering ten brave warriors to Isanami's side. Thus begins Brave 10, a story set in the Warring States period. It follows Saizou and Isanami's journey throughout the war-laden lands in search of brave warriors to serve under Yukimura's banner, each possessing powerful skills of their own. They'll have to travel far and wide, all while trying to fend off those who would chase after the dark power that she possesses to make it their own.

Demons have now become commonplace around the kingdom of Midland, which has fallen into chaos. The swordsman Guts still cannot stay in one place for long due to his demonic brand. He could always manage to protect himself when he was alone, but now he has the added challenge of protecting former Commander Casca, a shell of her former self who neither remembers nor trusts him. They never have a moment's rest with the constant threat of demons, and they need a place where Casca will be safe till they find a way to heal her. Their elf ally, Puck, tells of the mystical land of Elfhelm, which is supposed to be a safe haven from the demons that ravage the lands. Tired and with only a vague hope, they struggle on to find a place to live—and they still need to find those responsible for the madness they are forced to endure. [Written by MAL Rewrite]

Now branded for death and destined to be hunted by demons until the day he dies, Guts embarks on a journey to defy such a gruesome fate, as waves of beasts relentlessly pursue him. Steeling his resolve, he takes up the monstrous blade Dragonslayer and vows to exact vengeance on the one responsible, hunting down the very man he once looked up to and considered a friend. Along the way, he encounters some unlikely allies, such as a small elf named Puck, and Isidro, a young thief looking to learn swordsmanship from the former mercenary. As the ragtag group slowly comes together after having decided to join Guts in his quest, they will face incredible danger unlike anything they have ever experienced before. [Written by MAL Rewrite]